| Second-largest moon of Saturn | 29 |
| Second-largest moon in the solar system | 39 |
| Second-largest Mediterranean island | 35 |
| Second-largest Med. island | 26 |
| Second-largest living birds | 27 |
| Second-largest living bird | 26 |
| Second-largest land animal, briefly | 35 |
| Second-largest land animal | 26 |
| Second-largest lake in North America | 36 |
| Second-largest lake in Europe | 29 |
| Second-largest island in the Med. | 33 |
| Second-largest island | 21 |
| Second-largest Islam denomination | 33 |
| Second-largest Indian city | 26 |
| Second-largest human bone | 25 |
| Second-largest Hawaiian island | 30 |
| Second-largest Greek island | 27 |
| Second-largest Great Lake | 25 |
| Second-largest existing bird | 28 |
| Second-largest denomination of Islam | 36 |
| Second-largest deer | 19 |
| Second-largest country in Africa by area | 40 |
| Second-largest country | 22 |
| Second-largest continent | 24 |
| Second-largest cont. | 20 |
| Second-largest city on the Atlantic coast | 41 |
| Second-largest city of Rhode Island | 35 |
| Second-largest city of Italia | 29 |
| Second-largest city in the 46th state | 37 |
| Second-largest city in Oklahoma | 31 |
| Second-largest city in Nicaragua | 32 |
| Second-largest city in New Hampshire | 36 |
| Second-largest city in Kyrgyzstan | 33 |
| Second-largest city in Italy | 28 |
| Second-largest city in Finland | 30 |
| Second-largest city in Ark. | 27 |
| Second-largest Central American city | 36 |
| Second-largest bird | 19 |
| Second-largest Arab emirate in area | 35 |
| Second-in-command: abbr. | 24 |
| Second-in-command to Captain Kirk | 33 |
| Second-in-command in the kitchen | 32 |
| Second-in-command in a kitchen | 30 |
| Second-in-command | 17 |
| Second-highest-grossing film of 2003 | 36 |
| Second-highest world capital | 28 |
| Second-highest voice in a four-part chorus | 42 |
| Second-highest U.S. Army award | 30 |
| Second-highest pinochle cards | 29 |
| Second-highest pinochle card | 28 |
| Second-highest peak in the Cascades | 35 |
| Second-highest part, usually | 28 |
| Second-highest mountain in the lower 48 states | 46 |
| Second-highest mountain in the contiguous US | 44 |
| Second-highest mountain | 23 |
| Second-highest in four-part harmony | 35 |
| Second-highest course concentration, often | 42 |
| Second-highest choir voice | 26 |
| Second-helpings taker | 21 |
| Second-heaviest noble gas | 25 |
| Second-hand, say | 16 |
| Second-hand tire | 16 |
| Second-hand store transactions | 30 |
| Second-hand products | 20 |
| Second-hand producer? | 21 |
| Second-hand kind of shop | 24 |
| Second-hand items? | 18 |
| Second-hand item? | 17 |
| Second-hand gal of song | 23 |
| Second-hand deal | 16 |
| Second-hand circuit | 19 |
| Second-hand | 11 |
| Second-guessers' words | 26 |
| Second-guesser's forte | 26 |
| Second-growth crop | 18 |
| Second-greatest player of all time, in a 1997 "Hockey News" vote | 74 |
| Second-greatest period in the history of something | 50 |
| Second-generation shows | 23 |
| Second-generation senator from Indiana | 38 |
| Second-generation reggae artist | 31 |
| Second-generation Japanese/American | 35 |
| Second-generation Japanese-American | 35 |
| Second-generation Japanese in the U.S. | 38 |
| Second-generation Japanese American | 35 |
| Second-generation Japanese | 26 |
| Second-generation boxer Ali | 27 |
| Second-generation boxer | 23 |
| Second-generation Asian-American | 32 |
| Second-floor apartment | 22 |
| Second-fiddle | 13 |
| Second-deepest U.S. lake | 24 |
| Second-counter's opening | 28 |
| Second-commonest blood type: Abbr. | 34 |
| Second-column listing | 21 |
| Second-closest star to Earth | 28 |
| Second-class student? | 21 |
| Second-checkup action | 21 |
| Second-chance exams | 19 |
| Second-century year | 19 |
| Second-century pope | 19 |