| Four Seasons Hotel architect | 28 |
| Four seasons in Madrid | 22 |
| Four seasons in Seville | 23 |
| Four seasons in Sonora | 22 |
| Four Seasons number, e.g. | 25 |
| Four song releases, typically | 29 |
| Four thirds, for example | 24 |
| Four time AL batting champ | 26 |
| Four times a day, in an Rx | 26 |
| Four times a day, on an Rx | 26 |
| Four times a day: Abbr. | 23 |
| Four times a year: Abbr. | 24 |
| Four times daily, in an Rx | 26 |
| Four times what's left? | 27 |
| Four Tops frontman Stubbs | 25 |
| Four ways to get around | 23 |
| Four years as governor, say | 27 |
| Four years at 1600, e.g. | 24 |
| Four years in the White House | 29 |
| Four years, for a president | 27 |
| Four years, for the president | 29 |
| Four __ (theme of the puzzle) | 29 |
| Four ___ (whiskey brand) | 24 |
| Four, in prescriptions | 22 |
| Four, on some clock faces | 25 |
| Four, on some sundials | 22 |
| Four, six or seven attachment | 29 |
| Four- or five-star officer | 26 |
| Four-act Chekhov drama | 22 |
| Four-and-twenty blackbirds? | 27 |
| Four-armed destroyer of evil | 28 |
| Four-armed Hindu deity | 22 |
| Four-armed Hindu goddess | 24 |
| Four-digit number, at the ATM | 29 |
| Four-dimensional figure | 23 |
| Four-dimensional realm | 22 |
| Four-door automobiles? | 22 |
| Four-fifths of the atmosphere | 29 |
| Four-footed family member | 25 |
| Four-footed furry friends | 25 |
| Four-Grammy winner of 2006 | 26 |
| Four-hand piano pieces | 22 |
| Four-handed piano pieces | 24 |
| Four-handed piano tune | 22 |
| Four-handed poker games? | 24 |
| Four-in-hands for a polyglot? | 29 |
| Four-leaf clover cousin | 23 |
| Four-leaf clover, for some | 26 |
| Four-legged comfort giver | 25 |
| Four-legged Disney hero | 23 |
| Four-legged farmyard female | 27 |
| Four-legged Francis of film | 27 |
| Four-legged Hammett character | 29 |
| Four-legged Oz traveler | 23 |
| Four-legged Oz visitor | 22 |
| Four-legged visitor to Oz | 25 |
| Four-letter word, aptly | 23 |
| Four-letter words, sometimes | 28 |
| Four-letter-word concealer | 26 |
| Four-letter-word eliminator | 27 |
| Four-line biographical poem | 27 |
| Four-line rhyme scheme | 22 |
| Four-o'clock service? | 25 |
| Four-on-the-floor feature | 25 |
| Four-on-the-floor foursome | 26 |
| Four-on-the-floor item | 22 |
| Four-on-the-floor options | 25 |
| Four-on-the-floor, e.g. | 23 |
| Four-part harmony part | 22 |
| Four-player arcade classic | 26 |
| Four-poster and others | 22 |
| Four-ring-logo company | 22 |
| Four-sided campus space | 23 |
| Four-sided figure, for short | 28 |
| Four-song discs, briefly | 24 |
| Four-spot's inferior | 24 |
| Four-star hotel amenity | 23 |
| Four-star leader: Abbr. | 23 |
| Four-star officer: Abbr. | 24 |
| Four-star ratings, say | 22 |
| Four-star review, e.g. | 22 |
| Four-state farming region | 25 |
| Four-string instruments | 23 |
| Four-stringed guitars (var.) | 28 |
| Four-stringed instrument | 24 |
| Four-stringed instruments | 25 |
| Four-stringer at a luau | 23 |
| Four-termer's monogram | 26 |
| Four-thirds of DCCLIII | 22 |
| Four-time champ at Wimbledon | 28 |
| Four-time Daytona 500 winner | 28 |
| Four-time Emmy winner Woodard | 29 |
| Four-time Emmy-winning drama | 28 |
| Four-time Emmy-winning series | 29 |
| Four-time home-run leader | 25 |
| Four-time Indy 500 champ Al | 27 |
| Four-time Indy 500 champion | 27 |
| Four-time Indy 500 victor | 25 |
| Four-time Indy 500 winner | 25 |
| Four-time Indy 500 winner Al | 28 |