| Optical maser | 13 |
| Optical maladies | 16 |
| Optical layer | 13 |
| Optical item | 12 |
| Optical intrusion? | 18 |
| Optical instrument pointed at a moon of Saturn? | 47 |
| Optical instrument | 18 |
| Optical inflammation | 20 |
| Optical illusion question, "Which is longer, ___?" | 60 |
| Optical illusion illustrator | 28 |
| Optical illusion artist M.C. -- | 31 |
| Optical illusion artist | 23 |
| Optical illusion | 16 |
| Optical glass | 13 |
| Optical element | 15 |
| Optical disk reader | 19 |
| Optical devices | 15 |
| Optical device | 14 |
| Optical component | 17 |
| Optical body used to disperse light | 35 |
| Optical beams | 13 |
| Optical beam | 12 |
| Optical areas | 13 |
| Optical annoyances | 18 |
| Optical annoyance | 17 |
| Optical aid | 11 |
| Optic __ | 8 |
| Optic screens | 13 |
| Optic part | 10 |
| Optic membrane: Comb. form | 26 |
| Optic membrane | 14 |
| Optic layer | 11 |
| Optic activity during sleep | 27 |
| Opted to duck | 13 |
| Opted not to play | 17 |
| Opted for paper over plastic? | 29 |
| Opted for a new hair color | 26 |
| Opted for | 9 |
| Opted | 5 |
| Opt. opp. | 9 |
| Opt to play for pay | 19 |
| Opt to omit | 11 |
| Opt to drop | 11 |
| Opt out of the local union? | 27 |
| Opt not to save | 15 |
| Opt not to prevent | 18 |
| Opt not to pick? | 16 |
| Opt not to get carry-out | 24 |
| Opt not to fold | 15 |
| Opt not to charge, perhaps | 26 |
| Opt not to be a state of the Union | 34 |
| Opt in advance | 14 |
| Opt in | 6 |
| Opt for the window instead of the aisle? | 40 |
| Opt for the gold watch? | 23 |
| Opt for home cooking | 20 |
| Opt for first | 13 |
| Opt for ease | 12 |
| Opt for another hitch | 21 |
| Opt for a suit and tie | 22 |
| Opt for a career without the band | 33 |
| Opt for | 7 |
| Opt (to) | 8 |
| Opt | 3 |
| Ops. base | 9 |
| Ops's daughter | 18 |
| Ops' daughter | 17 |
| Opry station, once | 18 |
| Opry star with a price on her head? | 35 |
| Opry instruments | 16 |
| Opry instrument | 15 |
| Opry goer, perhaps | 18 |
| Opry adjective | 14 |
| Oprah's TV network | 22 |
| Oprah's symbol | 18 |
| Oprah's role in 2009's "The Princess and the Frog" | 68 |
| Oprah's role in "The Color Purple" | 48 |
| Oprah's production studio | 29 |
| Oprah's production company | 30 |
| Oprah's network | 19 |
| Oprah's moment? | 19 |
| Oprah's longtime personal trainer | 37 |
| Oprah's Life Lift, e.g. | 27 |
| Oprah's is famous | 21 |
| Oprah's friend | 18 |
| Oprah's favorite aquarium fish? | 35 |
| Oprah's doctor friend | 25 |
| Oprah's company | 19 |
| Oprah's character in "The Princess and the Frog" | 62 |
| Oprah's best-selling cook | 29 |
| Oprah's best friend | 23 |
| Oprah's "The Color Purple" costar | 47 |
| Oprah's ''The Color Purple'' role | 53 |
| Oprah Winfrey's company | 27 |
| Oprah Winfrey forerunner Phil | 29 |
| Oprah in "The Color Purple" | 37 |
| Oprah has more than one | 23 |
| Oprah and Ellen | 15 |
| Oprah and Dr. Phil, e.g. | 24 |
| Oprah and Dr. Phil's offerings | 34 |