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Answer:
WORRY
Possible Questions:
Trouble
Stew
Fret
Distress
Concern
Anxiety
Show concern
Cause of wrinkles
"What, me ___?"
Lose sleep over (with "about")
Lose sleep over
Dog or hound
Be fretful
''What, me ___?''
Topic of quotation below
Kind of beads
It "often gives a small thing a big shadow": old proverb
Fret or chafe
End of Alfred E. Neuman's slogan
Cause of fitful sleep
"What, me ___?": Alfred E. Neuman line
"Interest paid on trouble before it falls due," per W. R. Inge