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Answer:
TOBACCO
Possible Questions:
Havana, e.g.
Snuff stuff
Slow-burning leaf
Put that in your pipe and smoke it
Nightshade family member
Jamestown crop
Contents of some pouches
Virginia crop
Unhealthy stuff that's cured
Road of stage fame
Powerful Washington lobby
Popular vice
Pipe filler
Pipe fill
Meerschaum input
It goes up in smoke
Crop with a powerful Washington lobby
Certain road
Cash crop for the southern American colonies
Caldwell's "__ Road"
Basic ingredient?
"___ Road," Caldwell novel