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Answer:
POISON
Possible Questions:
Corrupt
Contaminate
Kind of pen
Bane
Skull-and-crossbones stuff
Toxic substance
Borgia potion
Pesticide
Exterminator's option
Whodunit staple
Hemlock, for one
What Mr. Yuk labels
Weapon alternative in mysteries
Toxin
Toxicant
Staple of Agatha Christie mysteries
Something harmful
Scull-and-crossbones stuff
Negative influence
Murder method in Christie's "A Pocket Full of Rye"
Feature of many a whodunit
Arsenic, for one
Arsenic, e.g.
Arsenic e.g.
Arrow application
Another man's meat
"Every Rose Has Its Thorn" monster-balladeers