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Answer:
PIUSI
Possible Questions:
Second-century pope
First of 12 popes
Sainted pope
Pope, circa 140–55
Pope who died in A.D. 157
Pope between Hyginus and Anicetus
First of twelve popes
First of 12 popes with a religious-sounding name
First of 12 popes (just put the Roman numeral in now and get the name from the crossings)
Early pope