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Answer:
MALADY
Possible Questions:
Bug
Complaint
Disorder
Affliction
Ailment
Undesirable condition
Illness
Food poisoning, e.g.
Chronic ailment
Bug, perhaps
Sickness
Unwholesome situation
Serious ailment
Long-term indisposition
Indisposition
Coryza or yaws, e.g.
Coryza or yaws
Arthritis, e.g.
"But love's a ___ without a cure": Dryden