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Answer:
HEADACHE
Possible Questions:
Worry
Bother
Nuisance
Annoyance
Big bother
Aspirin target
Problem
Ibuprofen target
Pain in the brain
Cephalalgia
Migraine, e.g.
Major inconvenience
Bothersome type
Big problem
Annoying situation
Annoying problem
Vexing situation
Vexatious problem
One reason for taking aspirin
Migraine, for one
Migraine
Major annoyance
Hangover symptom
Big pain
Annoying person or situation
Acute problem