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Answer:
GALL
Possible Questions:
Irritate
Vex
Chutzpah
Rub the wrong way
Sass
Audacity
Moxie
Rankle
Impudence
Cheek
Effrontery
Nerve
Chafe
Rancor
Bitterness
Brass
Cheekiness
Temerity
Crust
Some nerve
Chutzpa
Chutzpah, in the extreme
Brazen boldness
Some nerve!
More than irk
Brazenness
Boldness to a fault
Unmitigated stuff
Annoy no end
Real nerve
It may be unmitigated
Irritate big-time
A lot of nerve
Wormwood's companion
Unmitigated ___
Rub sore
Really steam
Presumptuousness
Nerve, found in eight of the Across answers
Irritate greatly
Chutzpah in the extreme
Bitter substance
___ bladder