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Answer:
DESPAIR
Possible Questions:
Give up
Heartache
Gloom
Hopeless
Lose hope
Hopelessness
Lose heart
Hopeless feeling
Give up hope
Low state
Bad thing to sink into
Abandon hope
Very blue state
Postloss reaction, sometimes
Lose all hope
Film noir feature
Down state
"Shall I wasting in ___ . . . "
___, Inc. (company that sells demotivational posters)