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Answer:
CRUX
Possible Questions:
Essence
Gist
Heart
Point
Core
Nitty-gritty
Main point
Heart of the matter
Central point
Thrust
Pivotal point
Meat
Essential point
Nub
Critical point
Central idea
Key point
Decisive point
Pivotal part
Centre
Central feature
Basic point
Vital point
Most important point
Main feature
Unsolved question
The most important point
Key target of resolution
Decisive stage
Centre point
Central point, as of an argument