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Answer:
ASTUDYINSCARLET
Possible Questions:
Sherlock Holmes story
Holmes adventure
Story by A. Conan Doyle
Sherlock Holmes's first appearance, colorfully
Seminal mystery of 1887
Liquid asset for the Baker Street Irregulars
Great sleuth's debut
First Sherlock Holmes book: 1887
Doyle story
Doyle classic
Debut of Sherlock Holmes
Classic case for Sherlock