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Answer:
AMESIOWA
Possible Questions:
Skunk River city
City north of Des Moines
City on the Skunk River
Midwest university site
City where the Cyclones of the Big 12 compete
Central American city
Billy Sunday's birthplace
Where George Washington Carver studied
Setting of Jack Trice Stadium
Midwest city with a prominent straw poll
Jack Trice Stadium setting
Home to the Big 12's Cyclones
Hawkeye State city
Cyclones home